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Læknablaðið - 15.12.2011, Blaðsíða 22

Læknablaðið - 15.12.2011, Blaðsíða 22
RANNSOKN Heimildir 1. Benediktsdóttir B, Guðmundsson G, Jörundsdóttir KB, Vollmer W, Gíslason Þ. Hversu algeng er langvinn lungnateppa? - íslensk faraldsfræðirannsókn. Læknablaðið 2007; 93: 471-7. 2. Cooper JD, Patterson GA, Sundaresan RS, et al. Results of 150 consecutive bilateral lung volume reduction procedures in patients with severe emphysema. J Thorac Cardiovasc Surg 1996; 112:1319-29; discussion 29-30. 3. McKenna RJ, Jr., Benditt JO, DeCamp M, et al. Safety and efficacy of median stemotomy versus video-assisted thoracic surgery for lung volume reduction surgery. J Thorac Cardiovasc Surg 2004; 127:1350-60. 4. Yusen RD, Lefrak SS, Gierada DS, et al. A prospective evaluation of lung volume reduction surgery in 200 consecutive patients. Chest 2003; 123:1026-37. 5. Cooper JD, Trulock EP, Triantafillou AN, et al. Bilatcral pneumectomy (volume reduction) for chronic obstmctive pulmonary disease. J Thorac Cardiovasc Surg 1995; 109: 106-16; discussion 16-9. 6. Russi EW, Stammberger U, Weder W. Lung volume reduction surgery for emphysema. Eur Respir J 1997; 10: 208-18. 7. Kotloff RM, Tino G, Palevsky HI, et al. Comparison of short-term functional outcomes following unilateral and bilateral lung volume reduction surgery. Chest 1998; 113: 890-5. 8. Fishman A, Martinez F, Naunheim K, et al. A randomized trial comparing lung-volume-reduction surgery with medical therapy for severe emphysema. N Engl J Med 2003; 348: 2059-73. 9. Date H, Goto K, Souda R, et al. Bilateral lung volume reduction surgery via median stemotomy for severe pulmonary emphysema. Ann Thorac Surg 1998; 65:939-42. 10. Wilkens H, Demertzis S, Konig J, Leitnaker CK, Schafers HJ, Sybrecht GW. Lung volume reduction surgery versus conservative treatment in severe emphysema. Eur Respir J 2000; 16:1043-9. 11. Miller JD, Berger RL, Malthaner RA, et al. Lung volume reduction surgery vs medical treatment: for patients with advanced emphysema. Chest 2005; 127:1166-77. 12. Brantigan OC, Mueller E, Kress MB. A surgical approach to pulmonary emphysema. Am Rev Respir Dis 1959; 80: 194-206. 13. Criner G, Cordova FC, Leyenson V, et al. Effect of lung volume reduction surgery on diaphragm strength. Am J Respir Crit Care Med 1998; 157:1578-85. 14. Martinez FJ, de Oca MM, Whyte RI, Stetz J, Gay SE, Celli BR. Lung-volume reduction improves dyspnea, dynamic hyperinflation, and respiratory muscle function. Am J Respir Crit Care Med 1997; 155:1984-90. 15. Ciccone AM, Meyers BF, Guthrie TJ, et al. Long- term outcome of bilateral lung volume reduction in 250 consecutive patients with emphysema. J Thorac Cardiovasc Surg 2003; 125:513-25. 16. Geddes D, Davies M, Koyama H, et al. Effect of lung-volume-reduction surgery in patients with severe emphysema. N Engl J Med 2000; 343: 239-45. 17. Szekely LA, Oelberg DA, Wright C, et al. Preoperative predictors of operative morbidity and mortality in COPD patients undergoing bilateral lung volume reduction surgery. Chest 1997; 111:550-8. 18. Ramsey SD, Shroyer AL, Sullivan SD, Wood DE. Updated evaluation of the cost-effectiveness of lung volume reduction surgery. Chest 2007;131: 823-32. 19. Weder W, Tutic M, Lardinois D, et al. Persistent benefit from lung volume reduction surgery in patients with homogeneous emphysema. Ann Thorac Surg 2009;87:229- 36; discussion 36-7. 20. Kotloff RM, Tlno G, Bavaria JE, et al. Bilateral lung volume reduction surgery for advanced emphysema. A comparison of median stemotomy and thoracoscopic approaches. Chest 1996;110:1399-406. 21. DeCamp MM, Blackstone EH, Naunheim KS, et al. Patient and surgical factors influencing air leak after lung volume reduction surgery: lessons leamed from the National Emphysema Treatment Trial. Ann Thorac Surg 2006; 82: 197-206; discussion -7. 22. Daniel TM, Chan BB, Bhaskar V, et al. Lung volume reduction surgery. Case selection, operative technique, and clinical results. Ann Surg 1996; 223:526-31; discussion 32-3. 23. Brenner M, McKenna RJ Jr, Gelb AF, Fischel RJ, Wilson AF. Rate of FEVl change following lung volume reduction surgery. Chest 1998; 113: 652-9. 24. Shah PL, Slebos DJ, Cardoso PF, et al. Bronchoscopic lung-volume reduction with Exhale airway stents for emphysema (EASE trial): randomised, sham-controlled, multicentre trial. Lancet 2011; 378:997-1005. ENGLISH SUMMARY Lung volume reduction surgery for severe pulmonary emphysema in lceland Gunnarsson Sl, Johannsson KB, Gudjonsdottir M, Jonsson S, Beck HJ, Magnusson B, Gudbjartsson T Introduction: Lung volume reduction surgery (LVRS) can benefit patients with severe emphysema. The aim of this study was to evaluate the outcome of LVRS performed in lceland. Materials and methods: A prospective study of 16 consecutive patients who underwent bilateral LVRS through median sternotomy between January 1996 and December 2008. All patients had disabling dyspnea, lung hyperinflation, and emphysema with upper lobe predominance. Preoperatively all patients underwent pulmonary rehabilitation. Spirometry, lung volumes, arterial blood gases and exercise capacity were measured before and after surgery. Mean follow-up time was 8.7 years. Results: Mean age was 59.2 ± 5.9 years. All patients had a history of heavy smoking. There was no perioperative mortality and survival was 100%, 93%, and 63% at 1, 5, and 10 years, respectively. The forced expiratory volume in 1 second (FEV,) and the forced vital capacity (FVC) improved signi- ficantly after surgery by 35% (p<0.001) and 14% (p<0.05), respectively. The total lung capacity, residual volume and partial pressure of C02 also sho- wed statistically significant improvements but exercise capacity, 02 consumption and diffusing capacity of the lung for CO did not change. Prolonged air leak (a7 days) was the most common complication (n=7). Five patients required reoperation, most commonly for sternal dehiscence (n=4). Conclusion: In this small prospective study, FEV, and FVC increased and lung volumes and PaC02 improved after LVRS. Long term survival was satis- factory although complications such as reoperations for sternal dehiscence were common and hospital stay therefore often prolonged. Key words: Lung volume reduction surgery (LVRS), emphysema, lung function, complications, outcome, survival. 686 LÆKNAblaðið 2011/97 J
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