Læknablaðið - 15.12.2000, Page 53

FRÆÐIGREINAR / DOKTORSVÖRN
Nýr doktor í
bæklunarskurðlækningum
Þorvaldur
Ingvarsson
Key words: hip, OA THR,
prevalence, age standardiation,
inheritance, gene.
Þorvaldur Ingvarsson bæklunarskurðlæknir varði
þann 19. október síðastliðinn doktorsritgerð sína við
bæklunarlækningadeild Háskólasjúkrahússins í
Lundi. Ritgerðin ber heitið Prevalence and
Inheritance of Hip Osteoarthritis in Iccland.
Andmælandi var Micheal Doherty prófessor.
Leiðbeinendur voru Stefan Lohmander prófessor
og Gunnar Hagglund dósent.
Enskt ágrip ritgerðarinnar fer hér á eftir:
Hereditary factors are suggested to contribute to
osteoarthritis (OA), but their relative importance is
uncertain. Moreover, the underlying specific
variations at the genome level remain unknown. The
prevalence of hip OA in Iceland was assessed by
examining colon radiographs and was found to be at
least 5-fold higher compared to Sweden and
Denmark. The age-standardized incidence of total
hip replacement (THR) for primary hip OA in
Iceland between 1982 and 1996 was determined and
found to be 50 percent higher than in Sweden. A
comparison of two methods for estimating hip OA
from colon radiographs showed that a simple
quantitative method of measuring joint space was
more reliable than a qualitative method. The
contribution of heritability to hip OA leading to
THR was investigated by combining information
from two population-wide databases in Iceland: a
national register of all THR and a database of all
Icelandic genealogy records. A genetic contribution
to THR for OA was shown by identifying a large
number of familial clusters of THR for OA, and by
showing that OA patients descended from fewer
founders than matched controls, the kinship
coefficient among patients with THR for OA was
greater for than matched controls, and the relative
risk for siblings of THR for OA patients was 3.1 (2.5,
3.1). Icelandic patients with THR for OA are thus
significantly more related to each other than the
general Icelandic population. Finally, a genome locus
with a lod score of 2.58 was identified on
chromosome 16p by a genome wide scan of a large
Icelandic family with primary hip OA. These findings
support a significant genetic contribution to a
common form of OA and encourage the continued
search for genes conferring an increased
susceptibility to OA.
Fræðigreinar íslenskra lækna í erlendum tímaritum
Sendið hciti greinar, nöfn höfunda og birtingarstað.
Miðað er við greinar sem birst hafa á yfirstandandi og
síðasta ári. Til glöggvunar verður íslenskra höfunda
getið með fornafni þótt svo hafi ekki verið við
birtingu.
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