Læknaneminn


Læknaneminn - 01.10.1996, Side 62

Læknaneminn - 01.10.1996, Side 62
I Helicobacter pylori - yfirlitsgrein inant H. pylori ureasa og hefur það reynst veita góða vörn í músum (92), Auk þess að koma í veg fyrir H. pylori sýkingar með bólusetningum hefur verið reynt að uppræta H. pylori sýkingar í músum með bólusetrtingum. Við þær til- raunir var ureasa undireining B gefin p.o. og voru nið- urstöðurnar mjög lofandi (93). Þessar rannsóknir og fleiri svipaðar gefa góðar vonir um að í framtíðinni verði hægt að bólusetja gegn H. pylori og mögulega útrýma þessari sýkingu sem í dag er ein algengasta króníska bakteríusýkingin sem hrjáir mannkynið. NIÐURLAG Helicob.aeter pylori sýking er ein algengasta króníslca bakteríusýkingin sem hrjáir mannkynið. Þó tilvist bakteríunnar hafi ekki verið þekkt nema í 14 ár hafa þau ár verið viðhurðarrík. Gífulegar framfarir hafa orð- ið í meðferð ætisára á þessum tíma. Framtíðin á síðan eftir að leiða í ljós hvort hægt verði að meðhöndla H. pylori sýkingar á einfaldan hátt, eða jafnvel bólusetja gegn bakteríunni. Ef hægt væri að útrýma H. pylori hér á landi má búast við að það myndi ekki einungis nánast útrýma ætisárum, heldur einnig hugsanlega fækka tilfellum af magakrabbameini verulega. HEIMILDIR: 1. Kornberg HL, Davies RE, Wood DR: The activity and function of gastric urease in the cat. Bioehem J 1954, 56.'363-372 2. Von Korff RW, GUck D: Role.of urease in the gastric mucosa. II. In vitro studies with isotopic urea on frog mucosa. Am J Physiol 1951, 165:688-694 3. Zbarsky SH, Wright WD: The metabolism of C14- urea in the rat. Can J Med Sci. 1953,31:151-161 4. Bode G, Malfertheiner P, Lehnhardt G, Nilius M, Ditschuneit H: UltrastructuraJ localization of urease of Helicobacter pylori. Med Microbiol Immunol 1993, 182:233-242 5. Hazetl Sl, Evans DJ jr,. Graham DYí Helico.bacter pylori catalase. J Gen Microbiol 1991, 13,7:57 6. Inamoto Y, Hamanaka S, Hamanaka Y, Nagate T, Kondo I, Takemoto T, Okita K: Lipid eomposition and fatty acid analysis of Helicobacter pylori. J Gastroenterol 1995, 30(3);315<-318 7. Megraud F: Microbiological eharacteristi'cs of Campylobaeter pylori. Eur J Gastroenterol Hepatol 1989 1:5-12 8. Blaser MJ: The baeteria behind' ulcers. Scientific American 1996, February: 92-97 9. Karl G. Kristinsson, Erla Sigvaldadóttir, Bjarni Þjóðleifsson: Al- gengi mótefna gegn Helicobacter pylori á Islandi. Læknablaðið 1996, 82:366-370. 10. Malaty HM, Kiro JG, Kim SD, Graham DY: Prevalence of Helic- obacter pylori infection in Korean children: inverse relation to soci- oeconomic status despite a uniformly high prevalence in adults. Am J Epidemiol 1996, 143:257-262 11. Neale KR, Logan RP: The epidemiology and transmission of Helic- obacter pylori infeccion in children. Alim Pharm Ther 1995, 9 Suppl 2:77-84 12. Whitaker CJ, Dubiel AJ, Galpin OP: Social and geographic factors in Helicobacter pylori infection. Epidemiol Infect 1993, 111:63-70 13. Replogle ML, Glaser Sl, Hiatt RA, Parsonnet J: Biologic sex as a factor for Helicobacter pylori infecton in healthy young adults. Am J Epidemiol 1995, l42(8):856-863 14. Shahamat M, Mai U, Paszko-Kolva C, Kessel M, Colwell RR: Use of autoradiography to assess viability of Helicobacter pylori in wa- ter, Appl Environ Microbiol 1993, 59:1231-1235 15. Vanzweet AA, Thijs JC, Kooistrasmid AMD, Schirm J, Snijder JAM: Use ofPCR with feces for detection of Helicobacter pylori in- fection in patients. J Clin Microbiol 1994, 32:1346-134810. 16. Luman W, Alkout AM, Blackwell CC, Weir DM, Palmer KR: Helicobacter pylori in the mouth - negative isolation from dental plaque and saliva. Eur J Gastroenterol & Hepatol 1996, 8:11-14 17. Handt LK, Fox JG, Dewhirst FE, Fraser GJ, Paster BJ, Yan LL, Rozmiarek H, Rufo R, Stalis IH: Helicobacter pylori isolated from the domestic cat: public health implication. Infection and imm- unity 1994, 62:2367-2374 18. Axon; ATR: The transmission of Helicobacter pylori: which theory fits the facts? Eur J Gastroenterol & Hepatol 1996, 8:1-2 19. Axon: Acute infection with Helicobacter pylori. In Helicobacter pylori basic mechanisms to clinicai cure. London: Kluwer Academ- íq 1994:407-412 20. Tytgat GNJ; Endoscopic transmission of Helicobacter pylori. Ali- ment Pharmacol Ther 1995; 9:105-110 21. Taylor D, Blaser M: The epidemiology of Helicobacter pylori in- fection. Epidemiol Rev 1991. 13:40-59 22. Wihoite SL, Ferguson D Jr, Soike DR , et al: Increased prevalence of Helicobacter pylori antibodies among nurses. Arch Intern Med 1993. 153:708-712 23. Luzza F, Maletta M, Imeneo M, Fabiano E, Doldo P, Biancone L, Pallone F: Evidence against an increased risk of Helicobacter pylori infection in dentists: a serological and salivary study. Eur J Gastroenterol Hepatol 1995, 7(8): 773-779 24. Goodwin CS, Blincow ED, Warren JR et al: Evaluation of culture techinques for isolating Campylobacter pyloridis from endoscopic biopsies, of gastric mucosa. J Clin Pathol 1985, 38:1127 25. Westblom TU: The comparative value of different diagnostic tests for helicobacter pylori. In Helicobacter pylori: biology and clinical practice. Boca Raton, Florida CRCPress; 1993:329-342 26. Schrader JA, Peck HV, Notis WM, Shaw P, Venezia RA: A role for culture in diagnosis of Helicobacter pylori-related gastric disease. Am J Gastroenerol 1993, 88:1729-1733 27. Sim JG, Kim EC, Seo JK: The role of serology in the diagnosis of Helicobacter pylori infection in children. Clin Pediatrics 1995, 34(9):458-462 28. Meyer B, Werth B, Beglinger C, Dill S, Drewe J, Vischer WA, Eggers RH, Bauer FE, Stadler GA: Helicobacter pylori infection in healthy people: a dynamic process? Gut 191,3 2,347-350 29. Hussan MO, Gottrand F, Turck D et al: Detection of H. pylori in saliva using monoclonal antibody. J Med Microbiol Virol Parasitol 1993 279:466 30. Eggers RH, Kulp A, Tegeler R, Liidtke FE, Lepsien G, Meyer B, Bauer FE: A methodological analysis of the 13C-urea breath test for the detection Helicobacter pylori infections: high sensitivity and specificity within 30 min using 75 mg of 13C-urea. Eur J Gastroenerolo Hepatol 2:437-444, 1990 31. Thijs WJ, Thijs JC, Kleibeyker JH, Elzinga H, Stellaard F: Evalu- ation of clinical and home performance of the 13C-urea breath test for the detection of Helicobacter pylori. Eur J Gastroenterol Hepatol 1995, 7(7):603-607 32. Slomiansky A, Schubert T, Cutler AF: 13C-urea breath test to con- firm eradication of Helicobacter pylori. AmJ Gastroenterol. 1995, 90(2)224-226 33. Moskowitz M, Konikoff FM, Peled Y, Santo M, Hallak A, Buja- nover Y, Tiomny E, Gilat T: High Helicobacter pylori numbers are associated with low eradication rate after triple therapy. Gut 1995, 36(6):845-847 34. Westblom TU, Phadnis S, Yang P, Czinn SJ: Diagnosis of Helic- obacter pylori infection by means of a polymerase chain reaction assay for gastric juice aspirates. Clin Infect Dis 1993, 16:367-371 35. Patel P, Khulusi S, Mendall MA, Lloyd R, Jazrawi R, Maxwell JD, Northfield TC: Prospective screening of dyspeptic patients by Helicobacter pylori serology. Lancet, 1995, 346(8986): 1315-1318 LÆKNANEMINN 52 2. tbl. 1996, 49. árg.
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