Læknablaðið : fylgirit - 01.08.1981, Page 67

TABLE 1. Titration to pH 3.0 of 1 ml of antacid with 0.1 M HCl. 60 RPM. at 37°C.
Antacid Ml of 0.1 M HCL at 120 min. 0 min % of final volume added 10 min 30 min 60 min
1. Novalucol forte (Hássle) 2. Mixt. Magnesii 53.6 ± 1.3 23 45 82 96
Hydroxidi (RAP) 3. Mixt Aluminii Hydroxidi Cum Magnesii 43.1 ± 0.1 94 96 97 99
Silicate 10% (RAP) 4. Gelatum Aluminii Hydroxidi 4% USP Cum Magnesii Silicate 10% 30.1 ± 0.3 34 42 60 83
(Delta) 5. Gelatum Aluminii 27.2 ± 2.2 29 42 60 80
Hydroxidi (Delta) 6. Mylanta Liquid 25.0 ± 0.5 8 18 50 98
(Parker-Davis) 7. Mixt. Aluminii 23.2 ± 0.9 21 39 78 93
Hydroxidi (RAP) 22.3 ± 0.2 7 16 34 65
8. Alminox Dak 77 (RHAP) 21.9 ± 1.0 11 29 69 88
9. Gelusil Suspension (Warner) 10. Gelatum Aluminii 21.6 ± 0.7 30 49 73 90
Hydroxidi 4% (AAP) 11. Gelatum Aluminii Hydroxidi 4% Cum 19.4 ± 2.5 8 27 63 88
Magnesii Hydroxidi 10% (AAP) 17.1 ± 0.8 31 47 73 89
TABLE 2. Retail prices of antacids per volume and yer neutralizing capacity.
In Vitro Neutray Retail Costs oj
lizing Price per Neutrar
Capasity Bottle Volume in Price lizing
(mmolf hcl) 1.10.80 Bottle per HCl
Antacid ml I. Kr. ml 1 ml I. Kr.
1. Novalucol Forte (Hássle) 500 ml 2. Mixt. Magnesii Hydroxidi 5.357 3733,- 500 7.466 1.39
(RAP) 500 g 4.311 1854,- 439 4.223 0.98
3. Mixt. Aluminii Hydroxidi C. Magnesii
Silicate 10% (RAP) 1000 g 4. Gelat'im Aluminii Hydroxiui 4% 3.016 4186,- 927 4.516 1.49
USP C. Magnesii Silicate 10% (Delta) 750 g 2.718 3067,- 652 4.704 1.73
5. Gelatum Aluminii Hydroxidi 4% USP (Delta) 750 g 6. Myianta Liquid (Parker-Davis) 2.502 3012,- 707 4.260 1.70
360 ml 2.320 4184,- 360 1.162 5.01
7. Mixt. Aluminii Hydroxidi
(RAP) 1000 g 2.232 4111,- 952 4.318 1.93
8. Alminox AK 77 (RHAP) 500 g 2.194 2484,- 487 5.101 2.32
9. Gelusil Suspension (Warner) 200 ml 2.159 2471,- 200 12.36 5.72
10. Gelatum Aluminii Hydroxidi 4%
(AAP) 750 g 1.940 3012,- 789 3.817 1.97
11. Gelatum Aluminii Hydroxidi 4%
Cum Magnesii Silicate 10% (AAP) 750 g 1.710 3067,- 750 4.089 2.39
The Retail Prices were obtained from the Official Price-List I and II October 1980.