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1) Patients (104) who underwent subtotal
thyroidectomy several years prior to the
Study.
2) Patients (23) who were given radioiodine as
a treatment for thyreotoxicosis.
3) Subjects (10) with normal thyroid function
but circulating thyroid antibodies.
4) Control group (107).
The TSH values for euthyroid subjects post
thyroidectomy and post radioiodine were signi-
ficantly higher than in the control group. Sub-
jects with circulating thyroid antibodies had an
increased response to TRH compared to con-
trols.
It is concluded that TSH is mainly useful
for excluding hypothyroidism, and euthyroid
subjects can have elevated TSH values up to
30 ag/ml. Those subjects though run a higher
risk of developing hypothyroidism later on
than subjects with low TSH.
HEIMILDIR
1. Aiexander, W.D., Gudmundsson, Th.V.,
Bluhm, Harden, RjMc G.: Studies of Iodine
Metabolism in Iceland. Acta Endocrinologi-
ca 46 (1964) 679-683.
2. Crooks, J., Tulloch, M.I., Turnbull, A.C.,
Davidsson, D., Skúlason, T., Snædal, G.:
Comparative Incidence of Goitre in Preg-
nancy in Iceland and Scotland.
3. Everet, D. et al.: British Medical Journal.
1973. 4. 129.
4. Hedley, A.J., Thjodleifsson, B., Donald D.,
Swanson Beck, J., Crooks, J., Chesters, M.I.,
Hall, R.: Thyroid Function in Normal Sub-
jects in Iceland and Northeast Scotland.
Clinical Endocrinology (1977), 7, 377-382.
5. Himsworth, R.K., Fraser, P.H.: British
Medical Journal 1973, 2, 295.
6. Lundström, B., Gillquist, J., Karlberg, B.,
Kágedal, B. & Tegler, L.: Thyroid Function
after Subtotal Resection for Hyperthyroid-
ism: A Prospective Study. European Jour-
nal of Clinical Investigation (1978) 8, 46-52.
7. Sigurjónsson, J.: Structure and iodine con-
text of thyreotoxic goiters in Iceland. Ame-
rican Journal of Pathology, 26, 1103-1113.
8. Thjodleifsson, B.: A Study of Graves Dis-
ease in Iceland. Acta Med. Scand. Vol. 198,
309-314, 1975.
9. Thjodleifsson, B., Hedley, A.J., Donald, D.,
Chesters, M.I., Kjeld, M., Swanson Beck,
Crooks, J., Michie, W., Hall, R.: Outcome
of sub-total Thyroidectomy for Thyreo-
toxicosis in Iceland and Northeast Scotland.
Clinical Endocrinology (1977) 7, 367-376.
10. Tulloch, M.I.: Faetors affecting thyroid
function in human pregnancy. Ph.D. Thesis,
1966, University of Aberdeen.
11. Wilkin, T., Storey, B.E., Isles, T.E., Crooks,
J„ Swanson Beck, J.: High TSH concen-
tration in „euthyroidism": explanation
based on control loop theory. British Medi-
cal Journal 1977, 1, 993-996.