Læknablaðið : fylgirit - 01.05.1982, Blaðsíða 92

90
was significantly elevated in three eases only.
In one the AFP phoved within normal limits
on repeat, while in the other two the fetuses
were thought to be dead at the time of amnio-
centeses. No case of a neural tube defect was
found. Eleven fetuses with chromosomal ab-
normalities were diagnosed. One of these could
not be confirmed on chromosomal analysis of
the aborted fetus and was considered to be a
cultural artefact. An additional five had
chromosomal variants, also present in one of
the parents. Cell culture failed completely in
3 cases. Ten of the chromosomally abnormal
fetuses were aborted (one aborted spontan-
eously) and also one fetus because of a meta-
bolic defect, GM, — gangliosidosis.
Of the 482 children delivered to this group,
14 were dysmature, 9 had congenital anomalies
and 2 were stillborn. No congenital defect, that
could have been diagnosed with the amnio-
centesis procedure, was subsequently found.
HEIMILDIR
1. Biering, G., Snædal, G.: Rhesusmál á Is-
landi. Læknablaðið, fylgirit 10, feb. 1980.
2. Tulinius, H., Hauksdóttir, H. og Bjarnason,
Ó.: Litningarannsóknir á vegum Erfða-
fræðinefndar Háskólans og Rannsóknastofu
Háskólans. Læknablaðið, vol. 54., 169-177,
1968.
3. Jensson, Ó., Hauksdóttir, H., Bjarnason, Ó.
og Tulinius, H.: Yfirlit um litningarann-
sóknir 1967—1975. Læknablaðið vol., 62, 127-
130, 1976.
4. Huddleston, J.F. and Carney, F.E.: Midtri-
mester Amniocentesis and Culture of Am-
niotic Fluid Cells. Clinical Obstetrics and
Gynecology. Vol. 19. No. 4: pp. 941-956, des.
1976.
5. Nörregaard-Pedersen, B.: Perification and
sensitive immunoelectrophoretical petectian
and Quantitation of Human alphafaeto-
protein. Clin.chim. acta 38: 163, 1972.
6. Seppálá, M.: Alpha fetoprotein in the
amniotic fluid in relation to neural tube
defects and other congenital/genetic dis-
order of the fetus: bls 297 in Amniotic
Fluid. Ecl. D.V., Fairweather, T.K.A.B.
Esker Excerpta Medica 1978.
7. Monk, A.M. and Goldie, D.J.: The Signifi-
cans of Raised Maternal Serum alpha-feto-
protein Levels. B.J. Obst & Gyn 83 : 845-852,
1976.
8. Broch, D.J.H., Scrimgeour, J.B., Nelson,
M.M.: Amniotic fluid alpha-fetoprotein
measurements in the early prenatal dia-
gnosis of Central nervous system disorders.
Clinical Genetics 1975 : 7, 1963-169.
9. Goodnes, D.M.: Prenatal Genetic Diagnosis:
A historic prespective. Clinical Obst. & Gyn.
Vol. 19 no. 4 : 835-840, des. ’76.
10. Leoffler, F.E.: Amniocentesis. Journal of
the Royal Society of Medicine, Vol. 72. Oct.
1979, 715-716.
11. Simpson, L.J., Martin, A.O.: Prenatal dia-
gnosis of Cytogenetic disorders. Clinical
Obst. & Gyn. Vol 19 No. 4: 855-879, des. ’76.
12. Goodner, D.M.: Prenatal Genetic diagnosis:
Present and future. Clinical Obst. & Gyn.
Vol. 19 No. 4 : 973-980, des. ’76.