Læknablaðið - 15.01.2005, Blaðsíða 114

1 985-1 994 / ÁH/ETTUÞÆTTIR KRANSÆÐASJÚKDÓMA
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English summary
The Reykjavík Study 1967-1985: Risk factors for coro-
nary heart disease mortality have been investigated in a
prospective study of 8001 randomly selected lcelandic
men and 8468 women. The men were aged 34-64 and
the women 34-76 at the time of their first examination.
After followup from 2-17 years 1140 (14.2%) of the men
and 537 (6.3%) of the women had died. Coronary heart
disease accounted for 43% of the mortality among the
men, cancer 27% and cerebrovascular disease 7%. This
distribution is in contrast to what was found among the
women. Coronary heart disease accounted for 19.4% of
the mortality, cancer 42.3% while the relative contribu-
tion of cerebrovascular mortality was similar.
The effects of various factors were assessed
simultaneously with multivariate survival analysis using
the Cox's proportional hazard model. Age, serum total
cholesterol, triglycerides, smoking and systolic blood
pressure were all significant independent risk factors for
coronary heart disease mortality in both sexes. Fasting
blood sugar was of borderline significance, reaching sig-
nificance among men, but not among women. However,
since the women have much lower risk of dying from
coronary heart disease than the men the absolute risk
associated with each of the risk factors is much lower in
the women.
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