Læknablaðið - 15.01.2005, Page 114

1 985-1 994 / ÁH/ETTUÞÆTTIR KRANSÆÐASJÚKDÓMA
11. Cox DR. Regression models and life tables. J Stat Soc 1972; 34
(Series B): 187-220.
12. Castelli WR The epidemiology of coronary heart disease. The
Framingham study. Am J Med 1984; 76:4-12.
13. Stamler J, Wenthworth D, Neaton JD (for the MRFIT Research
Group). Is relationship between serum cholesterol and risk of
premature death from coronary heart disease continuous and
graded? Finding in 356.222 primary screenes of the Multiple
Risk Factor Intervention Trial /MRFIT). JAMA 1986; 256:2823-
8.
14. Shaper AG, Pocock SJ, Walker M, Cohen NM, Whale CJ, Thom-
son AG. British Regional Heart Study: Cardiovascular risk fac-
tors in middle-aged men in 24 towns. BMJ 1981; 283:179-86.
15. Carlson LA, Böttiger LE. Risk factors of ischemic heart dis-
ease in men and women. Results of the 19-year follow-up of the
Stockholm prospective study. Acta Med Scand 1985;218: 207-11.
16. Keys A, ed. Coronary heart disease in seven countries. Circula-
tion 1970; 41-42/Suppl. 1:1-211.
17. Woolf N. Pathology of atherosclerosis. Br Med Bull 1990; 46:
960-85.
18. The Lipid Research Clinics Coronary Primary Prevention Trial
Results I. Reduction in incidence of coronary heart disease. Lip-
id Research Clinics Program. JAMA 1984; 251: 351-64.
19. Blankenhorn DH, Nessim SA, Johnson RL, Sanmarco ME,
Azen SP, Cashin-Hemphill L. Beneficial effects of combined
colestipol-niacin therapy on coronary atherosclerois and coro-
nary venous bypass grafts. JAMA 1987; 257: 3233-40.
20. Bush TL, Fried LP, Barett-Connor E. Cholesterol, lipoproteins
and coronary heart disease in women. Clin Chem 1988; 34: B60-
B70.
21. Corrao JM, Becker RC, Ockene IS, Hamilton GA. Coronary
heart disease risk factors in women. Cardiology 1990; 77/Suppl.
2: 8-24.
22. Welin L, Larson B, Svardsbudd K, Eriksson H, Wilhelmsen L,
Tibblin G. Triglyserider, en kontroversiell riskfactor för hjárt-
infarkt. Nya syn fra studien „1913 árs man“. Stockholm: Svenska
Lákarsállskapets Riksstámma 1988; Sammanfattningar, 185-6.
23. Castelli WP. The trioglyceride issue: A view from Framingham.
Am Heart J 1986; 122:432-7.
24. Sigurðsson G, Baldursdóttir Á, Sigvaldason H, Agnarsson U,
Thorgeirsson G, Sigfússon N. Predictive value of coronary artery
disease in men. Am J Cardiol 1992; 69:1251-4.
25. Rosenberg L, Palmer JR, Shapiro S. Decline in the risk of myo-
cardinal infarction among women who stop smoking. N Engl J
Med 1990; 332:213-21.
26. Medical Research Council Working Party: MRC trial of treat-
ment of mild hypertension: principal results. BMJ 1985; 292: 97-
104.
27. Kannel WB, Dawber TR, McGee DL. Perspectives on systolic
hypertension. The Framingham study. Circulation 1986; 61:
1179-82.
28. Zanchetti A. Diastolic, systolic and 25 hour blood pressure:
Which should be treated? International Society of Hypertension
1988, Hypertension Annual; 1988:3-19.
29. Holme I. Drug treatment of mild hypertension to reduce the risk
of CHD: Is it worth-while? Stat Med 1988; 7:1109-20.
English summary
The Reykjavík Study 1967-1985: Risk factors for coro-
nary heart disease mortality have been investigated in a
prospective study of 8001 randomly selected lcelandic
men and 8468 women. The men were aged 34-64 and
the women 34-76 at the time of their first examination.
After followup from 2-17 years 1140 (14.2%) of the men
and 537 (6.3%) of the women had died. Coronary heart
disease accounted for 43% of the mortality among the
men, cancer 27% and cerebrovascular disease 7%. This
distribution is in contrast to what was found among the
women. Coronary heart disease accounted for 19.4% of
the mortality, cancer 42.3% while the relative contribu-
tion of cerebrovascular mortality was similar.
The effects of various factors were assessed
simultaneously with multivariate survival analysis using
the Cox's proportional hazard model. Age, serum total
cholesterol, triglycerides, smoking and systolic blood
pressure were all significant independent risk factors for
coronary heart disease mortality in both sexes. Fasting
blood sugar was of borderline significance, reaching sig-
nificance among men, but not among women. However,
since the women have much lower risk of dying from
coronary heart disease than the men the absolute risk
associated with each of the risk factors is much lower in
the women.
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