Læknaneminn


Læknaneminn - 01.04.1996, Side 50

Læknaneminn - 01.04.1996, Side 50
lyfjameðferð gegn sýkingu af völdum alnæmisveiru - ný viðhorf endanlegan árangur lyíjameðferðar gegn alnæm- isveiru enda eru menn minnugir vonbrigða sem ný lyf gegn sjúkdómnum hafa valdið á árum áður. HEIMILDIR 1. Wei X et al. Viral dynamics in human immunodeficiency virus type 1 infection. Nature 1995; 373: 117. 2. Ho DD et al. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 1995; 373: 123. 3. Volberding PA. HIV quantification. Lancet 1996; 347: 71. 4. Wain-Hobson S. Viral Burden in AIDS. Nature 1993; 366: 22. 5. Pantaleo G et al. HIV infection is active and progressive in lymphoid tissue during the clinical latent stage of disease. Nature 1993; 362: 355. 6. Embretson J et al. Massive covert infection of helper T lymphocytes and macrophages by HIV during the incuba- tion period of AIDS. Nature 1993; 362; 359. 7. Thomas RO et al. HIV- 1 RNA levels and time to AIDS. 3rd Conference on Retroviruses and Oportunistic Infect- ions, Jan 28 - Feb 2, 1996, Washington, DC. 8. Mellors JW et al. Prognosis in HIV-1 infection predicted by the quantity of virus in plasma. Science 1996; 272: 1167. 9. O’Brien WA et al. Changes in plasma HIV-1 RNA and CD4+ lymphocyte counts and the risk of progression to AIDS. N EnglJ Med 1966; 334: 426. 10. Current topics. Combinations, new drugs outperform AZT. ASM News 1995; 61: 620. 11. Voelker R. New studies say viral burden tops CD4 as a marker of HIV disease progression. JAMA 1996; 275: 421. 12. Stephenson J. New anti-HIV drugs and tratment strateg- ies buoy AIDS research. JAMA 1996; 275: 579. 13. Ho DD. Time to hit HIV early and hard. N Engl J Med 1995; 333: 450. 14. Kinloch-de Loes et al. A controlled trial of zidovudine in primary human immunodeficiency virus infection. N Engl J Med 1995; 333: 408. 15. Guðmundsson S. Lyfjameðferð gegn alnæmisveiru. Læknaneminn 1992; 45: 11. 16. Fischl MA et al. The efficacy of azidothymidine (AZT) in treatment of patients with AIDS and AIDS related comp- lex: a double blind, placebo controlled trial. N Engl J Med 1987; 317: 185. 17. Volberding PA et al. Zidovudine in asymptomatic human immunodeficiency virus infection: a controlled trial in persons with fewer than 500 CD4-positive cells per cubic millimeter. N Engl J Med 1990; 322: 941. 18. Aboulker J-P, Swart AM. Preliminary analysis of the Concorde trial. Lancet 1993; 341: 889 19. Volberding PA et al. A comparison of immediate with deferred zidovudine therapy for asymptomatic HlV-in- fected adults with CD4 cells count of 500 or more per cubic millimeter. N Engl J Med 1995; 333: 410-7 20. Cooper DA et al. Zidovudine in persons with asymptom- atic HIV infection and CD4 cell counts greater than 400 per cubic millimeter. N Engl J Med 1993; 329: 297 21. Kahn JO et al. A controlled trial comparing continued zidovudine with didanosine in human immunodeficiency virus infection, N Engl J Med 1992; 327: 581. 22. Abrams DI et al. A comparative trial of didanosine or zalcitabine after treatment with zidovudine in patients with human immunodeficiency virus infection. N Engl J Med 1994; 330: 657 23. Fischl MA et al. Combination and monotherapy with zidovudine and zalcitabine in patients with advanced HIV disease. Ann Intern Med 1995; 122: 24 24. Pollard R et al. Antiviral effect and safely of stavudine (d4T) and didanosine (ddl) combination therapy in HIV- infected subjects in an ongoing pilot randomized double- blinded Trial. 3rd Conference on Retroviruses and Opportunistic Infections, Jan 28 - Feb 2, 1996, Was- hington, DC. 25. Bartlett JA Long-term safety and efficacy of lamivudine (LMV) plus zidovudine (ZDV) compared with zalcitabine (ddC) plus ZDV in ZDV-experienced patients with absolute CD4+ cells = 100-300/mm3.3rd Conference on Retroviruses and Opportunistic Infections, Jan 28 - Feb 2, 1996, Washington, DC. 26. Eron B et al. Treatment with lamivudine, zidovudine, or both in HlV-positive patients with 200 to 500 cd4+ cells per cubic millimeter. N Engl J Med 1995; 333: 1662 27. Johnson VA et al. Drug resistance and viral load in NUCA 3002: lamivudine (3TC) (high or low dose)/zidovudine (ZDV) combination therapy versus ZDV/dideoxycytidine (ddC) combination therapy in ZDV-experienced (>=24 weeks) patients (CD4 cells 100-300/mm3). 3rd Confer- ence on Retroviruses and Opportunistic Infections, Jan 28 - Feb 2, 1996, Washington, DC. 28. Pagano PJ et al. In vitro inhibition of human immunodef- iciency virus type 1 by a combination of delavirdine (U- 901152) with protease inhibitor (U-75857). J Infect Dis 1995; 171:61. 29. Naiva M et al. Three dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1. Nature 1989; 337: 615. 30. Rosé JR, Craik CS. Structure-assisted design of nonpetide human immunodeficiency virus-1 protease inhibitors. Am J Respir Crit Care Med 1994; 150: S176. 31. Cameron B et al. Prolongation of life and prevention of LÆKNANEMINIM 44 1. tbl. 1996, 49. árg.
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