Læknablaðið - 15.05.1999, Blaðsíða 10

398
LÆKNABLAÐIÐ 1999; 85
D-vítamínhagur og árstíðabundnar
sveiflur í ýmsum aldurshópum
kvenna á íslandi
Gunnar Sigurösson1-2', Leifur Franzson13*, Hólmfríöur Þorgeirsdóttir4’, Laufey Steingrímsdóttir41
Sigurðsson G, Franzson L, Þorgeirsdóttir H,
Steingrímsdóttir L
Vitamin I) intake and serum 25-OH-vitamin D
concentration in different age groups of Icelandic
women
Læknablaðið 1999; 85: 398-405
Objective: The aim of this study was to evaluate the
vitamin D intake and serum concentrations of 25-
OH-vitamin D (25-OH-D) in different age groups of
Icelandic women. The seasonal variation of 25-OH-
D and its relationship with parathyroid hormone
(PTH) level was evaluated but some studies have
indicated that subclinical vitamin D deficiency may
lead to osteoporosis because of secondary elevations
of parathyroid hormone levels and subsequent bone
mineral release.
Material and methods: 25-OH-D was measured
(RIA, Incstar) in serum from the following age
groups of women; 12-15 years (n=325), 16, 18 and
20 years (n=247), 25 years (n=86), 34-48 years
(n=107) and in 70 years old (n=308). PTH (IRMA,
Nichols) was measured only in the 70 years old.
vitamin D intake was assessed by a standardized
food frequency questionnaire. The seasonal variation
of 25-OH-D was evaluated in the age group 12-15
years and 70 years old.
Results: In the different age groups the 25-OH-D
concentration was positively correlated to vitamin D
intake (r=0.2-0.54; p<0.05). The mean concentration
of 25-OH-D in 12-15 years old was 34.6+22 nmol/L
Frá "rannsóknarstofu um beinbrot og beinþynningu, z|lyf-
lækningadeild og 31rannsóknardeild Sjúkrahúss Reykja-
víkur, 4|Manneldisráöi Islands. Fyrirspurnir, bréfaskipti:
Gunnar Sigurösson lyflækningadeild Sjúkrahúss Reykja-
víkur. Sími: 525 1000.
Lykilorö: D-vítamín, árstíöasveiflur, kalkhormón.
compared to 53.9±20 nmol/L in the 70 years old,
p<0.01. The levels of the other age groups were in
between.
A marked seasonal variation in 25-OH-D was obser-
ved in the 12-15 years old with low vitamin D intake
whereas only a slight seasonal variation was noted in
the 70 years old with a mean vitamin D intake of 15
pg/day.
Conclusions: The vitamin D status amongst 70 years
old women in Iceland is good because of common
intake of codliveroil and vitamin D supplements
(83%). The desirable level for 25-OH-D in this age
group seems to be around 50 nmol/L and this level is
achieved by the intake of 15-20 pg/day (600-800
units) of vitamin D. Vitamin D deficiency is however
common amongst 12-15 years old during late winter.
Low serum 25-OH-D levels are also common
amongst the other age groups studied during late
winter. From the results it seems reasonable to
recommend that foods like milk should be fortified
with vitamin D in Iceland, especially during winter
time.
Keywords: 25-OH-vitamin D, parathyroid hormone,
seasonal variation, iceiandic women.
Ágrip
Markmið: Markmið rannsóknarinnar var að
meta neyslu D-vítamíns og bera saman við 25-
OH-vítamín D þéttni í sermi (25-OH-D) í ýms-
um hópum kvenna á aldursbilinu 12-70 ára.
Ennfremur vildum við kanna tengsl 25-OH-D
við magn kalkhormóns í sermi (parathyroid
hormone, PTH), en ýmislegt bendir til að
vægur skortur á D-vítamíni valdi beinþynn-
ingu, vegna lægri þéttni kalsíums í blóði sem
leiði til aukinnar framleiðslu kalkhormóns og
þar með til aukinnar losunar steinefna úr bein-
um.
Efniviður og aðferðir: 25-OH-D var mælt í
eftirfarandi hópum kvenna, sem valdir voru