Læknablaðið : fylgirit - 01.07.1978, Page 95

TABLE I. PHARMACOLOGICAL PROPERTIES OF ANTIRHEUMATIC DRUGS
DRUG DOSAGE FORM AND DAILY DOSE HALF UFE FROTEIN BINIHNG METABOLISM SIDE EFFECTS
Phenylbutazone lOOmg 200 mg tablets One 100 mg tablet three times á day 72 hours 987o bound to plasma albumin Completely metabollsed in Uver Bone marrow depression is most serious of many toxic effects
Oxyphen- butazone 100 mg tablets One tablet three times a day 72 hours 987o bound to plasma protein MetaboUsed in Uver Similar to phenylbutazone
Mefenamic acid 250 mg capsules 2 capsules three times a day Uncertain Strongly bound to plasma protein Oxydised in the Uver Diarrhoea in % of patients Coombs positive haemolytic anaemia
Flufenamic acid 200 mg capsules 1 capsule three times a day Uncertain Strongly bound to plasma protein OxydiBed in the Uver Same as mefenamic acid have
Ibuprofen 400 mg tablet 1 tablet three times a day 2 hours 99% bound to plasma albumin Glukuronidation Dyspepsia
Flurbiprofen 25 mg capsules 50 mg tablets 1-3 capsules 13 hours Not aequately elucidated Not adequately elucidated Dyspepsia
Naproxen 250 mg capsules 1-3 capsules 13 hours Extensively bound Glukuronidation Dyspepsia Rarely gastro- intestinal bleeding
Ketoprofen 50 mg capsules 1-2 capsules four times aday 8 hours Highly, but loosely bound Acylyl trans- in the liver Dyspepsia
Fenoprofen 300 mg capsules 1-3 capsules four times a day Uncertain 2 hours Extensive and strongly Glukuronidation Dyspepsia
Azapropazone 300 mg capsules One capsule 3-4 times in a day 7 8. 5 hours 7 12 hours Not adequately elucidated Largely ex- creted un- changed Hydroxylation Dyspepsia
Feprazone 200 mg tablets One tablet' three times a day Uncertain Highly bound Biotransfor mation Skin rashes
Tolmetin 200 mg tablet 1-2 four times a day 1-1.5 hours Highly bound Hepatic meta- boUte A Dyspepsia
Alclofenac 500 mg tablets 4-12 tablets per day 3.5hours Highly and tightly bound Not adequately elucidated Dyspepsia Skin rashes Vasculitis
Sulindac 100 mg tablets 1-2 tablet twice a day 20 hours Uncertain Reduction to sulfide (actlve product) in Uver OxidiBOd to ln- actlve sulfone and excreted in urlne Dyspepsia
Indomethacin 25 mg capsules 6 hours 90 per cent Glukuronidation Dyspepsia
3-4 capsules bound to plasma Headache
in a day proteins Dizziness
93