Læknablaðið : fylgirit - 01.12.1983, Qupperneq 49

Læknablaðið : fylgirit - 01.12.1983, Qupperneq 49
47 væri ekki á taugatengsl heldur á taugina sjálfa; aukin kalíumleiðni í frumuhimnunni leiddi til yfir- skautunar (hyperpolarizationar) og minnkaðs ert- anleika taugarinnar. Til stuðnings þessari kenn- ingu nefndu þeir m.a. niðurstöður okkar um áhrif metohexitals á kalíumstreymi sem áður voru nefndar. Pannig getur hver lítil uppgötvun orðið mikilvægur hluti í stærra púsluspili. Ég er sann- færður um að við eigum að reyna eftir fremsta megni að halda uppi grunnrannsóknum sem tengj- ast geðlæknisfræði við geðdeildir landsins, en það kostar þrautseigju og þolinmæði, því fátt krefst eins mikillar þolinmæði og grunnrannsóknir við erfiðar aðstæður. HEIMILDIR 1. Hodgin, A.L., Huxley, A.F.A. quantitative descrip- tion of membrane current and its aplication to con- duction and excitation in nerve. J. Physiol 1952; 117:500-44. 2. Singer, S.J., Nicholson, G.L. The fluid mosaic model of the structure of cell membranes. Science 1972; 175: 720-5. 3. Armstrong, C.M. Interaction of tetraethyl- ammonium ion derivatives with the potassium channels of giant axons. J Gen Physiol 1971; 58: 413-37. 4. Stevens, C.F. The acethylcholine receptor. Nature 1980; 298: 13-4. 5. Nelson, N„ Anholt, R„ Lindstrom, J., Montal, M. Reconstitution of purified acetylcholine receptors with functional ion channels in planar lipid bilayers. ProcNat Acad Sci USA 1980; 77 (5); 3057-61. 6. Kandel, E.R. Cellular insights into behavior and learning. The Harvey Lectures, Series 73, Academic Press Inc. N.Y. 1979. 7. Dodge, F.A., Fankenhaeuser, B. Membrane curr- ents in isolated frog nerve fibre under voltage clamp conditions. J Physiol 1958; 143: 76-90. 8. Sakmann, B„ Patlak, J„ Neher, E. Single acetyl- cholineactivated channels show burst-kinetics in presence of desensitizing concentration of agonist. Nature 1980;286:71-3. 9. Stevens, C.F. Study of membrane permeability changes by fluctuation analysis. Nature 1977; 270: 391-6. 10. Árhem, P„ Frankenhaeuser, B„ Kristbjarnarson, H. Inactivation of the potassium transport system of myelinated nerve in the presence of a cyclic iono- phore. Acta Physiol Scand 1982; 114: 593-600. 11. Kristbjarnarson, H„ Potassium current in myelinat- ed nerve. Thesis 1983. 12. Árhem, P„ Kristbjarnarson, H. A barbiturate- induced potassium permeability increase in the myelinated nerve membrane. Acta Physiol Scand 1981; 113: 387-92. 13. French, R.J., Shoukimas, J.J. Blockage of squid axon potassium conductance by internal tetra-N- alkylammonium ions of various sizes. Biophys J 1981; 34: 271-91. 14. Nicoll, R.A. Madison, D.V. General anesthetics hyperpolarize neurons in the vertebrate central nervous system. Science 1982; 217: 1055-6.
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