Læknaneminn - 01.10.1995, Page 102

Læknaneminn - 01.10.1995, Page 102
100 ARUM EFTIR PASTEUR orsök hafa reynst vera smitsjúkdómar. Má þar nefna hermannaveiki (Legionnaires disease) sem reyndist vera af völdum Legionellapneumophila og maga- og skeifugarnasár sem reyndust vera af völdum Helicobacterpylori. Með nýrri þekkingu er hægt að lækna þessa sjúkdóma. I töflu 3 er listi yfir sjúkdóma og sýkla sem fundist hafa á síðustu árum. Líklegt er að fleiri sjúkdómar eigi eftir að reynast vera smitsjúkdómar. Vaxandi þekking og tækni í sameindalíffræði gera okkur nú kleift að finna örverur sem er að finna í litlu magni og erfitt eða ómögulegt er að rækta. Lengi hafa menn talið líklegt að alvarlegir sjúkdómar eins og iktsýki, sarco-idosis og Crohns sjúkdómur kunni að vera smitsjúkdómar. Nýlegar rannsóknir benda einnig til þess að bakterían Chlamydia pneumoniae eigi þátt i kransæðasjúkdómum(lO). Það erþví ljós að enn er mikið starf óunnið í sýklafræði, bæði hvað varðar sýklalyfjaónæmi og “nýja smitsjúkdóma”. FRAMTÍÐIN Vaxandi sýklalyíjaónæmi og vandamál tengd þeim Nýjir smitsjúkdómar greindir með sameindalíffræðilegum aðferðum Leit og prófun nýrra sýklalyfja Þróun og prófun á nýjum bóluefnum Meiri áhersla á sýkingavarnir og forvarnir HEIMILDIR. 1. De Kruif P. Bakteríuveiðar. Þýðing Boga Ólafssonar. Reykjavík: Hið íslenzka þjóðvinafélag, 1935. 2. Microsoft-corporation. Encarta. Redmond, WA: Microsoft corporation, 1994. 3. Fleury H. Institut Pasteur - Towards a new century. Paris: Institut Pasteur, 1987: 4. Tomasz A. Multiple-antibiotic-resistant pathogenic bacteria. A report on the Rockefeller University Workshop. New England Journal of Medicine 1994;330( 17): 1247-51. 5. Kristinsson KG. [Multiresistant bacteria in a Scandinavian perspective]. [Review] [Swedish]. Nordisk Medicin 1995; 110(2):42-4. 6. Armstrong D, Neu H, Peterson LR, Tomasz A. The prospects of treatment failure in the chemotherapy of infectious diseases in the 1990s. Microbial Drug Resistance 1995; 1(1): 1-4. 7. Kristinsson KG, Hjalmarsdottir MA, Steingrimsson O. Increasing penicillin resistance in pneumococci in Iceland [letter]. Lancet 1992;339(8809): 1606-7. 8. Kristinsson KG. Epidemiology of penicillin resistant pneumococci in Iceland. Microbial Drug Resistance 1995; 1(2). 9. Kristinsson KG, Hjálmarsdóttir MÁ, Gudnason T. Epidemiology of penicillin resistant pneumococci in Iceland - Hope for the future? ICAAC. San Francisco: ASM, 1995. 10. Campbell LA, O’Brien ER, Cappuccio AL, et al. Detection of Chlamydia pneumoniae TWAR in human coronary atherectomy tissues. Journal oflnfectious Diseases 1995;171:585-588. 11. Satcher D. Emerging infections: getting ahead of the curve. Emerging Infectious Diseases 1995; 1 (1): 1 -6. 12. Bisliop RF, Davidson GP, Holmes II I, Ruck BJ. Virus particles in epithelial cells of duodenal mucosa from children with acute non- bacterial gastroenteritis. Lancet 1973;2:1281-1283. 13. Cossart YE, Field AM, Cant B, Widdows D. Parvovirus-like particles in human sera. Lancet 1975;1:72-73. 14. Nime FA, Burek JD, Page DL, Holscher MA, Yardley JH. Acute enterocolitis in a human being infected with the protozoan Cryptosporidium. Gastroenterology 1976;70:592-598. 15. Johnson KM, Webb PA, Lange JV, Murphy FA. Isolation and partial characterization of a new virus causing acute haemorrhagic fever in Zaire. Lancet 1977;1:569-571. 16. McDade JE, Shepard CC, Fraser DW, Tsai TR. Redus MA, Dowdle QR. Laboratory investigation team. Legionnaires’ disease. 2: Isolation of a bacterium and demonstration of its role in other respiratory disease. New England Journal of Medicine 1977;297:1197-1203. 17. Lee HW, Lee PW, Johnson KM. Isolation of the etiologic agent of Korean hemorrhagic fever. Journal of Infectious Diseases 1978;137:298-308. 18. Skirrow MB. Campylobacter enteritis: a new disease. British Medical Journal 1977;2:9-11. 19. Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JD, Gallo RC. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proceedings of the National Academy of Sciences 1980;77:7415-7419. 20. Schlievert PM, Shands KN, Gan BB. Schmid GP, Nishimura RD. Identification and characterization of an exotoxin from Staphylococcus auresu associated with toxic shock syndrome. Journal of Infectious Diseases 1981;143:509-516. 21. Riley LW, Remis RS, Helgerson SD, al e. Hemorrhagic colitis associated with a rare Escherichia coli serotype. New England Journal ofMedicine 1983;308:681-685. 22. Kalyanaraman S, Sarangadharan MG, Poiesz B, Ruscetti FW, Gallo RC. Immunological properties of a type C retrovirus isolated from cultured human T-lymphoma cells and comparison to other mammalian retroviruses. Journal of Virology 1981;38:906-915. 23. Burgdorfer W, Barbour AG, Hayes SF, Benach JL, Grunwaldt E, Davis JP. Lyme disease - a tick-borne spirochetosis? Science 1982;216:1317- 1319. 24. Barré-Sinoussi F, Chermann JC, Rey F, et. al. Isolation of a T- lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome. Science 1983;220:868-871. 25. Yamanishi K, Okuno T, Shiraki K, et al. Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet 1988;1:1065-1067. 26. Dawson JE, Anderson BE, Fishbein DB, et al. Isolation and characterization of an Ehrlichia sp. from a patient diagnosed with human ehrlichiosis. Journal ofClinical Microbiology 1991 ;29:2741 - 2745. 27. Choo QL, Kuo G, Weiner AJ, Overby LR, Bradley DW, Houghton M. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 1989;244:359-361. 28. Salas R, de Manzione N, Tesh RB, et al. Venezuelan hemorrhagic fever. Lancet 1991;338:1033-1036. 29. World-Health-Organization. Epidemic diarrhea due to Vibrio cholerae non-01. Weekly Epidemiological Records 1993;68:141-142. 92 LÆKNANEMINN 2,tbl. 1995 48. árg.
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